Year : 2020 | Volume
: 7 | Issue : 2 | Page : 235--239
Plasma epinephrine as a prognostic marker in traumatic brain injury
Ahmed E Elshewy1, Ahmed M Nabil2, Ehab M El-Reweny2
1 Resident of Critical Care in Alexandria University Students Hospital, Alexandria, Egypt
2 Critical Care Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Background Traumatic brain injury is an international health problem with high morbidity and mortality. It is associated with catecholamine release (catecholamine surge).
Objective The purpose of the work was to study plasma epinephrine as a prognostic marker in traumatic brain injury.
Patients and methods The authors enrolled 60 adult persons of both sexes [30 patients with diagnosis of isolated traumatic brain injury with Glasgow coma score (GCS) ≤11 and 30 volunteers as a control group]. Plasma epinephrine levels were measured on admission and after 24 h. Then the patients were classified into two groups at the end of the study (3 months) according to the GOS: group I (favorable outcome; GOS IV, V) which included 11 (36.6%) patients and group II (unfavorable outcome; GOS I, II, III) which included 19 (63.3%) patients.
Results Receiver operating characteristic curves were used to describe the prognostic value of plasma epinephrine on admission and after 24 h to predict unfavorable outcome and mortality. Higher levels of epinephrine on admission were associated with a higher rate of unfavorable outcome [areas under the curve (AUC)=0.921, confidence interval (CI): 0.828–1.014, P<0.001] and mortality (AUC=0.855, CI: 0.707–1.003, P=0.003). Also, higher levels of epinephrine after 24 h were associated with a higher rate of unfavorable outcome (AUC=0.971, CI: 0.912–1.030, P<0.001) and mortality (AUC=0.884, CI: 0.752–1.02, P=0.002).
Conclusion Plasma epinephrine could be used as a prognostic marker in traumatic brain injury.
MBBCh Ahmed E Elshewy
Faculty of Medicine, Alexandria University, 7 Syria Street, Roushdy, Alexandria, 21529
|How to cite this article:|
Elshewy AE, Nabil AM, El-Reweny EM. Plasma epinephrine as a prognostic marker in traumatic brain injury.Res Opin Anesth Intensive Care 2020;7:235-239
|How to cite this URL:|
Elshewy AE, Nabil AM, El-Reweny EM. Plasma epinephrine as a prognostic marker in traumatic brain injury. Res Opin Anesth Intensive Care [serial online] 2020 [cited 2020 Aug 5 ];7:235-239
Available from: http://www.roaic.eg.net/article.asp?issn=2356-9115;year=2020;volume=7;issue=2;spage=235;epage=239;aulast=Elshewy;type=0