Research and Opinion in Anesthesia & Intensive Care

REVIEW ARTICLE
Year
: 2017  |  Volume : 4  |  Issue : 3  |  Page : 99--107

Serial heparin-binding protein compared with sequential organ failure assessment, acute physiological and chronic health evaluation ii, multiple organ dysfunction and charlson scores as predictors of mortality in critically ill septic patients


Gamal Hamid Ibrahim1, Dalia Mohamed Ragab1, Amal Foad Rizk1, Nora Ismail Abbas1, Talal Ibrahim Hagag2 
1 Department of Critical Care Medicine, Cairo University, Cairo, Egypt
2 Department of Critical Care Medicine, Shebin Elkom Teaching Hospital, Al Minufiyah, Egypt

Correspondence Address:
Nora Ismail Abbas
Department of Critical Care Medicine, Cairo University, Cairo
Egypt

Introduction Early detection and management of severe sepsis is crucial for successful outcome. We hypothesized that the progression of sepsis to severe sepsis is preceded by vascular leakage, which is caused by neutrophil-derived mediators, as heparin-binding protein (HBP). Aim The aim of the study was to identify the role of serial HBP measurement as a predictor of morbidity and mortality in critically ill septic patients in comparison with sequential organ failure assessment (SOFA), acute physiological and chronic health evaluation II (APACHE II) score, multiple organ dysfunction (MODS) scores, and Charlson scores. Settings and design This was an observational prospective controlled study. Materials and methods Patients were classified into two groups: group I, which included 40 patients with evident sepsis; and group II (control group), which included 10 critically ill nonseptic patients. Results Statistically significant difference was detected between survivors and nonsurvivors in max SOFA score, APACHE II, MODS, white blood cells, and serial HBP. Receiver-operating characteristic curve using admission HBP for prediction of severe sepsis showed a sensitivity of 94.7% and specificity of 100% at cut-off level more than 1.9 ng/ml, and for prediction of mortality the sensitivity was 91.6% and specificity 100% at cut-off level more than 1.9 ng/ml. Conclusion Serial plasma HBP levels can predict severe sepsis and mortality in ICU septic patients without statistically significant difference compared with SOFA, APACHE, and MODS scores.


How to cite this article:
Ibrahim GH, Ragab DM, Rizk AF, Abbas NI, Hagag TI. Serial heparin-binding protein compared with sequential organ failure assessment, acute physiological and chronic health evaluation ii, multiple organ dysfunction and charlson scores as predictors of mortality in critically ill septic patients.Res Opin Anesth Intensive Care 2017;4:99-107


How to cite this URL:
Ibrahim GH, Ragab DM, Rizk AF, Abbas NI, Hagag TI. Serial heparin-binding protein compared with sequential organ failure assessment, acute physiological and chronic health evaluation ii, multiple organ dysfunction and charlson scores as predictors of mortality in critically ill septic patients. Res Opin Anesth Intensive Care [serial online] 2017 [cited 2017 Nov 18 ];4:99-107
Available from: http://www.roaic.eg.net/article.asp?issn=2356-9115;year=2017;volume=4;issue=3;spage=99;epage=107;aulast=Ibrahim;type=0