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Year : 2019  |  Volume : 6  |  Issue : 4  |  Page : 439-445

Does pregabalin reduce the sevoflurane requirement during laparoscopic cholecystectomy?

Department of Anaesthesia and Surgical ICU, College of Medicine, Mansoura University, Mansoura, Egypt

Correspondence Address:
MD Doaa G Diab
Department of Anaesthesia and Intensive Care, College of Medicine, Mansoura University, Mansoura, 35516
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/roaic.roaic_53_19

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Background Preoperative administration of pregabalin reduces the end-tidal concentrations of sevoflurane (ET-Sevo) during laparoscopic cholecystectomy with the added benefit of improving the quality of postoperative analgesia. Patients and methods After ethical approval, 43 patients scheduled for laparoscopic cholecystectomy were randomly allocated to receive placebo or 150 or 300 mg of pregabalin, 1 h before induction. Anaesthesia was maintained with 0.5–1.5 minimum alveolar concentration of sevoflurane, to maintain bispectral index at 50–60, with supplemental fentanyl and vecuronium. Changes in heart rate, mean blood pressure, ET-Sevo, quality of extubation and postoperative sedation scores, morphine consumptions and pain scores were recorded. Results After induction, compared with placebo and pregabalin 150 mg groups, patients receiving pregabalin 300 mg had smaller increases in heart rate (P<0.01), lower ET-Sevo (−45.5 and −42.9%, respectively) (P<0.001), better quality of extubation (P<0.001), higher sedation scores for first 8 postoperative hours (P<0.001), longer time to the first request of morphine (P<0.001), less morphine consumption (P<0.02) and lower pain scores (P<0.001) for the first 24 h after surgery. Conclusion Preoperative administration of pregabalin 300 mg is effective in reduction of the ET-Sevo during laparoscopic cholecystectomy without noted significant adverse effects.

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