• Users Online: 968
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2019  |  Volume : 6  |  Issue : 3  |  Page : 313-320

Presepsin as a predictor of sepsis outcome in comparison with procalcitonin and C-reactive protein

1 Critical Care Medicine Department, Beni Suef University, Beni Suef, Egypt
2 Critical Care Medicine Department, Cairo University, Giza, Egypt

Correspondence Address:
MD Khaled M Taema
7985 Almadeena Almonawara Street, Mokattam, Cairo 11571
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/roaic.roaic_52_18

Rights and Permissions

Introduction Identification of predicted sepsis-related mortality is important for patient stratification. We evaluated the significance of presepsin in predicting sepsis-related mortality. Patients and Methods We enrolled 83 patients with sepsis according to the SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference in a prospective observational study. Results After excluding 28 patients owing to different exclusion criteria, 55 continued the study. Their age was 58 (47–65) years old and comprised 33 (60%) males. We measured serum presepsin, procalcitonin (PCT), and C-reactive protein (CRP) on admission and 24 and 72 h later. Acute Physiology and Chronic Health Evaluation II score and capillary leak index were estimated. The primary outcome was in-hospital mortality. The median (Q1–Q3) presepsin24 and presepsin72 levels were 127.5 (835.75–2137.5) and 883 (429–1214.5) pg/ml, respectively, in survivors compared with 2321 (1264–3456) and 3421 (1900–5432) pg/ml, respectively, in nonsurvivors (P=0.01 and 0.000, respectively). The serum CRP24 and CRP72 were 123 (76–154) and 94 (42.5–127) mg/l, respectively, in survivors compared with 156 (101–201) and 187 (139–233) mg/l, respectively, in nonsurvivors (P=0.02 and 0.000, respectively). PCT72 was 111.5 (66–186.25) pg/ml in survivors compared with 231 (187–324) pg/ml in nonsurvivors (P=0.000). Presepsin0, CRP0, PCT0, and PCT24 were not significantly different between survivors and nonsurvivors (P=0.4, 0.7, 0.5, and 0.2, respectively). The Acute Physiology and Chronic Health Evaluation II score was 18 (15–20.8) in survivors compared with 21 (19–24) in nonsurvivors, (P=0.02), whereas the capillary leak index was 42 (27.6–57.7) and 42.4 (33.3–62.3) in survivors and nonsurvivors, respectively (P=0.8). The area under the curve was the highest for presepsin72 (0.918). Presepsin72 of 1262 pg/ml was seen to be 92.3% sensitive and 81.3% specific for mortality prediction. Conclusion This study showed that the serum presepsin could be a valuable biomarker for predicting in-hospital mortality in sepsis.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded86    
    Comments [Add]    

Recommend this journal