• Users Online: 163
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 5  |  Issue : 3  |  Page : 240-245

The role of brain natriuretic peptide in correlation to mitral annular plane systolic excursion in predicting sepsis-induced myocardial dysfunction


Department of Critical Care Medicine, Cairo University, Giza, Egypt

Correspondence Address:
Mohamed A Shehata
Department of Critical Care Medicine, Faculty of Medicine, Cairo University, Giza
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/roaic.roaic_97_17

Rights and Permissions

Introduction Sepsis is one of the leading causes of mortality and morbidity around the world. Myocardial dysfunction is one of the important factors in the hemodynamic compromise seen in sepsis. B-type natriuretic peptide (BNP) and mitral annular plane systolic excursion (MAPSE) are proposed to be useful markers in predicting sepsis-induced myocardial dysfunction (SIMD). Objective To signify the role of BNP, MAPSE, and their correlation in the prediction of SIMD. Patients and methods Forty patients diagnosed with sepsis or septic shock, in addition to 10 healthy volunteers were included in the study in the period from March 2016 to March 2017 in the Critical Care Department of Cairo University and Alexandria University. All patients were subjected to BNP measurement and echocardiography measuring MAPSE on admission and after 48 h with correlation of these measurements to sepsis-induced cardiomyopathy. Results The studied patients were divided into two groups. Group I: patients who did not develop myocardial dysfunction (n=16) and group II patients who developed myocardial dysfunction (n=24).There was statistically significant difference between both groups as regards BNP level and MAPSE both on admission and after 48 h with a P value of less than 0.001, with patients who developed sepsis-induced cardiomyopathy exhibiting higher levels of BNP and lower MAPSE. In addition, the current study demonstrated a strong negative correlation between MAPSE and BNP level on admission (P=0.004 and r=−0.572) and after 48 h (P=0.0030 and r=−0.444) in patients who developed myocardial dysfunction due to sepsis (group II). Conclusion Both BNP level and MAPSE could significantly predict sepsis-induced cardiomyopathy with a strong negative correlation found between BNP level and MAPSE both on admission and after 48 h in the prediction of SIMD.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed45    
    Printed0    
    Emailed0    
    PDF Downloaded11    
    Comments [Add]    

Recommend this journal