• Users Online: 414
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2018  |  Volume : 5  |  Issue : 1  |  Page : 1-7

Atherosclerotic plaque composition and significance of nonculprit intermediate coronary lesions. Intravascular ultrasound and quantitative coronary angiography study in acute coronary syndrome

Department of Critical Care, Faculty of Medicine, Cairo University, Cairo, Egypt

Correspondence Address:
Helmy H El Ghawaby
Department of Critical Care, Faculty of Medicine, Cairo University, Cairo, 11562
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/roaic.roaic_14_17

Rights and Permissions

Background Detection of potentially vulnerable plaques inducing acute coronary syndrome (ACS) improves prevention of cardiovascular events. We aimed at using intravascular ultrasound (IVUS) for morphological assessment, anatomical significance of atherosclerotic plaques of nonculprit intermediate coronary lesions and correlation with quantitative coronary angiography (QCA) in ACS. Patients and methods 2IVUS was performed on 61 nonculprit intermediate coronary lesions in 28 patients diagnosed with non-ST-elevation ACSs. Percent area stenosis more than 70% was the cutoff value for intervention. Results The mean age was 53.2±9.1 years, men=20 (71.4%). Culprit vessels represent 42% of affected vessels. Higher lipid content was found in lesions of culprit vessels (P<0.001). Six lesions were revascularized based on IVUS measures (QCA accuracy=90.1%, sensitivity=77.8%, and negative predictive value=85%). Minimal lumen area (MLA) and plaque burden are the main predictors for lesion anatomical significance with [P<0.001, odds ratio=0.25, 95% confidence interval (CI)=0.12–0.55] and (P=0.011, odds ratio=2.0, 95%CI=1.2–3.3), respectively. There was a positive strong correlation between QCA minimal lumen diameter and MLA (P<0.001, r=0.695). An inverse moderate correlation was seen between QCA minimal lumen diameter and percent area stenosis (P<0.001, r=−0.449). There was a significant concordance between QCA and IVUS regarding percent stenosis (P=0.01, intraclass correlation coefficient=0.451, 95%CI=0.084–0.67), while there was disconcordance in measurement of the lesion length (P=0.2, intraclass correlation coefficient=0.22, 95%CI=−0.3–0.53). Conclusion IVUS might be valuable for the assessment of nonculprit lesions in ACS. There is high vulnerability for plaque rupture in intermediate lesions of culprit vessels. MLA and plaque burden are the main predictors for lesion anatomical significance. QCA is a reliable tool for detecting severity of coronary artery disease.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded155    
    Comments [Add]    

Recommend this journal